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doi:10.1016/j.clnu.2020.06.015 38 Smedberg M

Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation

Long-term administration of advanced glycation end-product stimulates the activation of NLRP3 inflammasome and sparking the development of renal injury

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